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Hualan Liu an ENIGMA Researcher in Adam Deutschbauer‘s Lab at Lawrence Berkeley Lab announces a powerful genetic tool for gene function annotation, essential to advance our understanding of microbial biology and the impact of those genetic traits on their ecosystems.  She says “We developed a parts-based strategy for constructing and evaluating hundreds of transposon delivery […]
Parts-Based Strategy Speeds Up Gene Function Annotation
February 1, 2018
ENIGMA researchers at Lawrence Berkeley Lab and University of Missouri systematically used high-throughput genetics to fill gaps in amino acid biosynthesis pathways. This explains how bacteria can grow on their own, in contrast to widespread speculation that bacteria cross-feed amino acids among community members. According to Morgan Price, for many bacteria with sequenced genomes, we […]
Most Free-Living Bacteria Likely Make All 20 Amino Acids
January 11, 2018
ENIGMA researchers describe our proposed workflow as a general guideline for studying new environmental microbes in a fast and comprehensive way. Liu, H.; A.M. Deutschbauer (2018) Rapidly moving new bacteria to model‐organism status. Current Opinion in Biotechnology. DOI: 10.1016/j.copbio.2017.12.006 Currently there is a need to rapidly move new bacteria to “model organism” status, given the importance of […]
Rapidly Moving New Bacteria to Model Organism Status
January 8, 2018
ENIGMA’s Vivek Mutalik, Adam Deutschbauer, Pavel Novichkov and Adam Arkin win R&D100 Award for a tool developed under our “Discovery Program”; where high risk projects are funded for a short duration to encourage high impact changes in science or technological capability that extend and enhance our ongoing research Dub-seq technology is based on creating genomic fragment library […]
Dual Barcoded Shotgun Expression Library Sequencing (Dub-seq) wins R&D100 Award
November 20, 2017
ENIGMA researchers at University of Oklahoma, Lawrence Berkeley Lab, University of Washington, and University of Missouri reveal that the accumulation and induction of key cellular components persists in bacteria for greater than 5000 generations although the physiological and transcriptional responses to high salinity is altered. The mechanistic changes in evolved genotypes suggested that growth energy efficiency might […]
Key Cellular Components Persist in Bacteria Although Response to Salt Stress Changes
November 14, 2017

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