Lawrence Berkeley National Lab
Environmental Genomics & Systems Biology
Environmental Atlas Science Lead
amdeutschbauer@lbl.gov
(510) 643-5683
Adam Deutschbauer has a background in microbial systems biology. As Environmental Atlas Science Lead, he develops next-generation tools for microbial functional genomics. These tools drive the development of experimental approaches to develop models of microbial metabolism, gene regulation, and signal transduction. He supports the high-throughput processing of ENIGMA isolates, facilitating integration and collaboration between groups.
Relevant Publications
GenomeDepot: Data Management System for Microbial Comparative Genomics - GenomeDepot Enables Web-Based Annotation and Comparative Analysis of Microbial Genomes GenomeDepot is an open-source, web-based platform for microbial genome annotation, management, and comparative analysis. Built to help researchers quickly organize genome collections and explore genomic features, including ortholog families, protein domains, operons, regulatory interactions, and strain and sample metadata, GenomeDepot also enables interactive genome browsing, BLAST and annotation search, and… More →
New Origins of Replication Expand Our Toolkit for Understanding and Engineering Microbial Systems - Microbiology studies benefit immensely from the ability to genetically manipulate the bacterial strain of interest. Transition from purely genomic studies to genetics-enabled molecular biology approaches, often relies on plasmids, or small circular DNA elements distinct from the chromosome. In developing plasmid-based systems, knowledge of the origin of replication (the point at which DNA replication begins) that works with the bacteria’s… More →
ENIGMA researchers identify hundreds of new enzymes - Filling Gaps in Bacterial Metabolism with Computation and High-throughput Genetics: An analysis of genetic data from many different kinds of bacteria identified hundreds of new enzymes. More →
Uncovering metal tolerance mechanisms using ENIGMA tools and Analysis - Thorgersen, M.P., .; J. Xue, E.L.W. Majumder, V.V. Trotter, X. Ge, F.L. Poole II, T.K. Owens, L.M. Lui, T.N. Nielsen, A.P. Arkin, A.M. Deutschbauer, G. Siuzdak, and M.W.W. Adams Deciphering microbial metal toxicity responses using RB-TnSeq and activity-based metabolomics. Applied and Environmental Microbiology 87 (21), e01037-21 (2021). [DOI]: 10.1128/AEM.01037-21] {PMID}:34432491 OSTI:1825256 Deciphering Microbial Metal Toxicity using RB-TnSeq and Activity-Based… More →
Host Bacteria Are Helped By Viral Genomes - Kothari, Ankita.; S. Roux, H. Zhang, A. Prieto, J-M Chandonia, S. Spencer, X. Wu, A M. Deutschbauer, A. P. Arkin, E J. Alm, R. Chakraborty, A Mukhopadhyay (2021) Ecogenomics of groundwater viruses suggests niche differentiation linked to specific environmental tolerance. mSystems [doi]:1128/mSystems.00537-21 {PMID}: 34184913 PMCID: PMC8269241 OSTI:1807913 Niche Specific Genes from Phage Genomes are Advantageous for Communities of Groundwater Bacteria Ground water… More →
Discovery Support Yields Phage Tailocin Insights - April 7, 2021-To ensure that the ENIGMA research program remains vibrant 10% of funding is set aside annually for a Discovery program. ENIGMA researchers may propose new, short-term, research projects that either explore a new research theme or develop a new technical capability. These proposals are reviewed internally and funds allocated on the basis of merit and potential impact. One… More →