The Scripps Research Institute,
Dr. Siuzdak supports the systems biology guided by the metabolomics effort in the ENIGMA SFA. His team performs systems-level analysis initially from high accuracy mass spectrometry data acquisition by mapping the identified metabolites directly onto pathways and cross-integration with genomic data. They use tandem MS validation of the metabolites as part of the autonomous workflow for these analyses. This novel approach, designed as a cloud-based technology (XCMS Online) coupled with the METLIN database, is currently being used by over 45,000 scientists around the globe. He will employ it to help decipher denitrification processes as well as carbon fixation and sulfur biochemistry. XCMS Online coupled with METLIN will make it possible by employing both metabolomics with proteomics and genetic tools, recent advances in high-throughput screening, and microbial systems biology modeling.